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Peer-Reviewed Publications


14. C. Tang, W. Jing, K. Han,... D. Zhu, C. Chen, D. Zhang, D. Li, S. Ni, T. Li, J. Cut, X. Jiang (2024). mRNA-Laden Lipid-Nanoparticle-Enabled in Situ CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model. ACS Nano. Vol 18 (3). 2261-2278.


13. D. Zhu, DH. Brookes, A. Busia, .... J. Listgarten & DV. Schaffer (2024). Optimal trade-off control in machine learning–based library design, with application to adeno-associated virus (AAV) for gene therapy Science Advances. Vol 10 (4). adj3786.


12. Z. Yang, Y. Liu, K. Zhao, ... D. Zhu, C. Chen, X. Jiang (2023). Dual mRNA co-delivery for in situ generation of phagocytosis-enhanced CAR macrophages augments hepatocellular carcinoma immunotherapy. Journal of Controlled Release. Vol 360. 718-733.


11. D. Zhu, P. Trinh, E. Liu, F. Yang (2023). Cell–Cell Interactions Enhance Cartilage Zonal Development in 3D Gradient Hydrogels. ACS Biomaterials Science & Engineering. Vol 9 (2). 831-843. (Featured as internal cover)


10. D. Zhu, J. Chen, HJ. Johnson, DV. Schaffer (2021). Optogenetic applications for investigating cellular behaviors and neurological diseases.  Frontiers in Cellular Neuroscience.Vol 16. 811493.

9. D. Zhu, AJ. Schieferecke, PA. Lopez, DV. Schaffer (2021). Adeno-associated virus vector for central nervous system gene therapy. Trends in Molecular Medicine. Vol 27 (6), p524-537. (Featured as journal cover and Trends talk) 

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8. D. Zhu*, D. Brookes*, A. Busia, et al., J. Listgarten, D.V. Schaffer (2021). Machine learning-based library design improves packaging and diversity of adeno-associated virus (AAV) libraries. Biorxiv. 


7. D. Zhu, P. Trinh, J. Li, GA. Grant, F. Yang (2021). Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cell fates in 3D.  Journal of Biomedical Materials Research Part A. Vol 109 (6), p1027-1035. 

6. D. Zhu*, E. Liu*, E. Gonzalez Diaz, X. Tong, F. Yang (2020). Gradient hydrogels for optimizing niche cues to enhance cell-based cartilage regeneration. Tissue Eng Part A. Vol 27 (13-14), p929-939. 


5. D. Zhu, P. Trinh, E. Liu, F. Yang (2018). Biochemical and mechanical gradients synergize to enhance cartilage zonal organization in 3D. ACS Biomaterials Science & Engineering. Vol 4 (10), p3561-3569.


4. D. Zhu*, H. Wang*, P. Trinh, S. Heilshorn, & F. Yang (2017). Elastin-like Protein-Hyaluronic acid (ELP-HA) Hydrogels with Decoupled Mechanical Property and Polymer Composition for Cartilage Formation. Biomaterials. Vol 127, p132-140. 


3. D. Zhu, X. Tong, P. Trinh, J. Lai, & F. Yang (2017). Mimicking Cartilage Tissue Zonal Organization by Engineering Tissue-scale Gradient Hydrogels as 3D Cell Niche. Tissue Eng Part A. Vol 24 (1-2), p1-10. (Highlight in EurekAlert News!) 

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2. H. Wang, D. Zhu, L. Cai, S. Heilshorn, & F. Yang (2017). Covalently adaptable elastin-like protein-hyaluronic acid (ELP-HA) hybrid hydrogels with secondary thermoresponsive crosslinking for injectable stem cell delivery. Advanced Functional Materials.  Vol 27, Issue 28, 1605609 (Featured as journal cover) 


1. D. Zhu, G. Schmunk, TJ. Nowakowski, DV. Schaffer (2020) Adeno-associated virus virions and methods of use thereof. US Patent No. 63/094,820

2. D. Zhu, D. Brookes, J. Listgarten, DV. Schaffer (2021). Improving Packaging and Diversity of AAV Libraries with Machine Learning. U.S. Provisional Patent. No. 17/453,068. 

3. D. Zhu, A. Carneiro, DV. Schaffer (2023). Long-Read Sequencing of Diverse DNA Libraries through Barcode-Labeled Short Reads (BLaSR). U.S. Provisional Patent. No. 63/500, 501.

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